A broad spectrum and highly bioavailable multivitamin and mineral, BioFoundation-G’s formulation uses clinically driven research to provide the nutritional foundation needed for the modern environment. This complete multi contains clinical doses of nutrients such as N-acetyl-L-cysteine and R-alpha-lipoic acid, well established to increase cellular levels of glutathione, the most prevalent intercellular antioxidant.1,2,3 Glutathione is one of the most important conjugators of numerous environmental and endogenous toxins. It is known to be depleted not only by xenobiotics, but also by chronic conditions such as diabetes, as well as inflammatory and neurodegenerative diseases.4,5,6,7,8,9
Glutathione support is linked to lower rates of cell death and apoptosis.10 BioFoundation-G provides physiologically relevant doses of hepatoprotectors such as milk thistle, antioxidants, mitochondrial bioenergetic enhancers such as CoQ10, and co-factors for critical detoxification enzymes.11,12 It contains 2000 IU vitamin D3, 45 mcg vitamin K2 and 200 mg niacinamide per serving, more than most existing multivitamin formulas.13,14 It also provides the biological modifiers natural trans resveratrol and green tea phytosome, nutrients shown to have anti-inflammatory, anti-obesity, anti-aging, cardiovascular, and stress related benefits.15,16,17,18
Benefits
- Provides rate limiting nutrients for glutathione production, necessary for xenobiotic detoxification
- Full spectrum multiple vitamin and mineral, with 2000 IU vitamin D3 per serving
- Contains clinical doses of resveratrol, lipoic acid, CoQ10, milk thistle and green tea extract
- Broad spectrum antioxidant support, including bilberry and citrus extracts, lipoic acid, lycopene and lutein
- Highly bioactive and bioavailable nutrients, such as pyridoxal-5-phosphate and vitamin K2 (Menaquinone 7)
Ingredients
Serving Size: 6 Tablets
Servings per Container: 30
Each Tablet Contains:
Vitamine A (Palmitate) ...............................................500 IU (150 mcg RAE)
Vitamin B1 (Thiamine Hydrochloride).........................4.2 mg
Vitamin B2 (Riboflavin) ..............................................4.2 mg
Vitamin B3 (Niacin) ...................................................12.5 mg
Vitamin B3 (Niacinamide) .........................................33.3 mg
Vitamin B5 (Pantothenic Acid/Calcium d-Pantothenate) ......16.7 mg
Vitamin B6 (Pyridoxine Hydrochloride/Pyridoxal 5-Phosphate)....2.5 mg
Biotin .........................................................................................8.3 mcg
Betaine Hydrochloride .....................................................16.7 mg
Folic Acid (Folate) ............................................................83 mcg
Vitamin B12 (Methylcobalamin) ......................................167 mcg
Para-Aminobenzoic Acid (PABA) ......................................4.2 mg
Choline (Bitartrate) ..........................................................4.2 mg
Inositol ............................................................................4.2 mg
Vitamin C (Ascorbic Acid) .............................................167 mg
Vitamin D3 (Cholecalciferol) ........................333 IU (8.3 mcg)
Vitamin E (d-Gamma-Tocopherol) ....................33.3 mg
Vitamin K2 (Menaquinone) (MK-7) (Natto Bean) ..........7.5 mcg
Boron (Citrate) ...........................................................41.7 mcg
Calcium (HVP* Chelate) ..............................................16.7 mg
Chromium (Polynicotinate) ........................................33.3 mcg
Copper (HVP* Chelate) .............................................170 mcg
Iodine (Ascophyllum nodosum) (whole plant) ............50 mcg
Magnesium (HVP* Chelate) ..........................................33.3 mg
Manganese (Citrate) .........................................................0.8 mg
Molybdenum (Citrate)....................................................66.7 mcg
Potassium (Citrate) ...........................................................6.8 mg
Selenium (Selenomethionine) .........................................33.3 mcg
Vanadium (Citrate) .........................................................2.5 mcg
Zinc (Citrate) ...................................................................2.5 mg
Bilberry Extract (Vaccinium myrtillus) (fruit) (36% Anthocyanosides) .........................6.6 mg
Citrus Bioflavonoids 4:1 Extract (Citrus limon, Citrus sinensis, Citrus paradisi) (fruit) ....8.3 mg
Coenzyme Q10 (Microorganism) ...................................8.3 mg
Green Tea Phytosome® (Camellia sinensis, Glycine max) (leaf, seed) (13% EGCG**) ....8.3 mg
Hesperidin (Citrus sinensis) (fruit) ................................4.2 mg
Lutein (Tagetes erecta) (herb flowering oleoresin) ............550 mcg
Lycopene (Lycopersicon esculentum) (fruit) ......................280 mcg
Silybin Phytosome® (Silybum marianum, Glycine max) (fruit, seed) ....25 mg
N-acetyl-L-cysteine .....................................................25 mg
R-alpha-Lipoic Acid ..............................................................41.7 mg
ResveratrolRich® Proprietary Blend [Wine Grape (Vitis vinifera) (fruit), Purified Japanese Knotweed (Polygonum cuspidatum) (root)] ...........33.3 mg
Providing Natural Trans-Resveratrol ................................................16.7 mg
*HVP: Hydrolyzed Vegetable Protein
**EGCG: epigallocatechin-3-gallate
Non-medicinal Ingredients
Microcrystalline cellulose, croscarmellose sodium, coating (carbohydrate gum [cellulose], glycerin), vegetable grade magnesium stearate (lubricant).
Allergens
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, yeast, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Recommended Adult Dose
3 tablets per day with meals, 2 hours before or after taking other medications, or as directed by a health care practitioner.
Contraindications
Consult a health care practitioner if you are taking blood thinners, or if you are pregnant or breastfeeding. Consult a health care practitioner prior to use if you have diabetes or kidney stones, or if you are taking sulfonamides or blood pressure medication. Consult a health care practitioner prior to use if you are taking prescription medication, as resveratrol may alter the effectiveness of these medications. Hypersensitivity (e.g., allergy) has been known to occur, in which case discontinue use. Do not use this product if you are taking antibiotics or nitroglycerin. Keep out of reach of children.
Drug Interactions
Vitamin K supplementation may decrease the efficacy of warfarin, or require more close monitoring of its administration.19 This product contains nutrients known to reduce hypertension and hyperglycemia, and may require lower dosing or discontinuation of related medications.
References
1. Atkuri KR, N-Acetylcystein–a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9.
2. Shay KP, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009 Oct;1790(10):1149-60.
3. Moraes TB, Dalazen GR, Jacques CE, et al. Glutathione metabolism enzymes in brain and liver of hyperphenylalaninemic rats and the effect of lipoic acid treatment. Metab Brain Dis. 2014 Sep;29(3):609-15.
4. Awasthi YC, et al. Physiological and pharmacological significance of glutathione-conjugate transport. J Toxicol Environ Health B Crit Rev. 2009 Aug;12(7):540-51.
5. Ludewig G, et al. Mechanisms of toxicity of PCB metabolites: generation of reactive oxygen species and glutathione depletion. Cent Eur J Public Health. 2000 Jul;8 Suppl:15-7.
6. Ahmed T, Endosulfan-induced apoptosis and glutathione depletion in human peripheral blood mononuclear cells: Attenuation by N-acetylcysteine. J Biochem Mol Toxicol. 2008 Sep;22(5):299-304.
7. Lee DH, et al. Serum gamma-glutamyltransferase: new insights about an old enzyme. J Epidemiol Community Health. 2009 Nov;63(11):884-6.
8. Treweeke AT, Winterburn TJ, Mackenzie I, et al. N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial. Diabetologia. 2012 Nov;55(11):2920-8. doi: 10.1007/s00125- 012-2685-z.
9. Ljubisavljevic S, Stojanovic I, Cvetkovic T, et al. Glutathione homeostasis disruption of erythrocytes, but not glutathione peroxidase activity change, is closely accompanied with neurological and radiological scoring of acute CNS inflammation. Neuroimmunomodulation.2014;21(1):13-20.
10. Circu ML, Aw TY. Glutathione and modulation of cell apoptosis. Biochim Biophys Acta. 2012 Oct;1823(10):1767-77.
11. Rosenfeldt F, Marasco S, Lyon W, et al. Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue. J Thorac Cardiovasc Surg. 2005 Jan;129(1):25-32.
12. Kiruthiga PV, Shafreen RB, Pandian SK, et al. Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes. Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):414-9.
13. Schurgers LJ, et al. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83.
14. Logan VF, Gray AR, Peddie MC, et al. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr. 2013 Mar 28;109(6):1082-8. doi: 10.1017/S0007114512002851.
15. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-42.
16. Fröjdö S, et al. Metabolic effects of resveratrol in mammals--a link between improved insulin action and aging. Curr Aging Sci. 2008 Dec;1(3):145-51.
17. Brasnyó P, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011 Mar 9:1-7. [Epub ahead of print]
18. Di Pierro F, Menghi AB, Barreca A, et al. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern Med Rev. 2009 Jun;14(2):154-60.
19. Ford SK, Misita CP, Shilliday BB, et al. Prospective study of supplemental vitamin K therapy in patients on oral anticoagulants with unstable international normalized ratios. J Thromb Thrombolysis. 2007 Aug;24(1):23-7.
