The only lipid-soluble endogenously synthesized antioxidant, CoQ10 (ubiquinone) has well established roles as a free radical scavenger in both mitochondrial and lipid membranes, as an electron carrier essential to cellular respiration and ATP production and recently has it has been shown to influence gene expression.^1,2,3,4

Given the central role of CoQ10 in mitochondrial function and cellular antioxidant protection, its clinical applications are extensive. Just a few of the many health conditions associated with requiring supplemental CoQ10 to boost levels are: general antioxidant support, cardiovascular disease (high blood pressure, congestive heart failure, cardiomyopathy, protection during cardiac surgery, high cholesterol being treated by drugs, especially statins), cancer (to boost immune function and/or offset chemotherapy side effects), diabetes mellitus, male infertility, Alzheimer’s (prevention) and Parkinson’s disease (prevention and treatment), periodontal disease and macular degeneration.^{5,6,7,8,9,10,11} The reduced form of CoQ10, ubiquinol, has emerged as a more effective therapy for increasing plasma levels of CoQ10 than most forms of ubiquinone due to its increased solubility.¹²

Benefits

Increases plasma levels of CoQ10 significantly more per mg compared to ubiquinone
Allows for higher peak plasma levels of CoQ10 especially when higher plasma CoQ10 are required
Ubiquinol is a highly absorbable and bioavailable form of CoQ10
Kaneka QH brand ubiquinol is naturally produced via yeast fermentation and is free of the impurities of synthetically processed CoQ10
Genetically modified organism (GMO) free, allergen free and Kosher certified

Ingredients

Serving Size: 1 Softgel
Servings per Container: 60

Each softgel Contains:
Ubiquinol (Kaneka QH^® Ubiquinol) (Microorganism) ......................100 mg
(Bioactive and Reduced Form of CoQ10)
Organic Flaxseed Oil (Linum usitatissimum) (seed) .......................... 297 mg

Non-medicinal Ingredients

Softgel (gelatin, glycerin, purified water, carob), yellow beeswax, non-GMO sunflower lecithin, natural vitamin E.

Allergens

Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Recommended Adult Dose

1 softgel 1–3 times per day or as directed by a health care practitioner.

Contraindications

Consult a health care practitioner prior to use if you are taking blood pressure medication or blood thinners, or if you are pregnant or breastfeeding. Keep out of reach of children.

Drug Interactions

Although existing evidence has not found an interaction, CoQ10 resembles vitamin K structurally, potentially interfering with the anticoagulant warfarin. Close monitoring of the INR is recommended with CoQ10 introduction in these patients. No other negative drug interactions are known for CoQ10, though a number of medications are thought to interfere with CoQ10 synthesis or function in the body, including statin medications, tricyclic antidepressants and oral hypoglycemic agents.¹³

References

1. Potgieter M, Pretorius E, Pepper MS, et al. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev. 2013 Mar;71(3):180-8.
2. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Nutrition. 2010 Mar;26(3):250-4. doi: 10.1016/j.nut. 2009.08.008.
3. Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7.
4. González-Guardia L1, Yubero-Serrano EM2, Delgado-Lista J, et al. Effects of the Mediterranean Diet Supplemented With Coenzyme Q10 on Metabolomic Profiles in Elderly Men and Women. J Gerontol A Biol Sci Med Sci. 2014 Jul 1. pii: glu098. [Epub ahead of print]
5. Gao L, Mao Q, Cao J, et al. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Atherosclerosis. 2012 Apr;221(2):311-6. doi: 10.1016/j.atherosclerosis.2011.
6. Rosenfeldt FL, Haas SJ, Krum H, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007 Apr;21(4):297-306.
7. Shults CW, Flint Beal M, Song D, et al. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp Neurol. 2004 Aug;188(2):491-4.
8. Villalba JM, Parrado C, Santos-Gonzalez M, et al. Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Expert Opin Investig Drugs. 2010 Apr;19(4):535-54.
9. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):641-6.
10. Molyneux SL, Florkowski CM, George PM, et al. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.
11. Safarinejad MR, Safarinejad S, et al. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol. 2012 Aug;188(2):526-31. doi: 10.1016/j.juro.2012.03.131.
12. Failla ML1, Chitchumroonchokchai C, Aoki F. Increased Bioavailability of Ubiquinol Compared to That of Ubiquinone Is Due to More Efficient Micellarization during Digestion and Greater GSH-Dependent Uptake and Basolateral Secretion by Caco-2 Cells. J Agric Food Chem. 2014 Jul 23;62(29):7174-82. doi: 10.1021/jf5017829. Epub 2014 Jul 9.
13. Bonakdar RA, Guarneri E. Coenzyme Q10. Am Fam Physician. 2005 Sep 15;72(6):1065-70.